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논문/논문리뷰

Network Analysis Identifies Regulators of Basal-Like Breast Cancer Reprogramming and Endocrine Therapy Vulnerability

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https://cancerres.aacrjournals.org/content/early/2021/11/26/0008-5472.CAN-21-0621.long

 

Network Analysis Identifies Regulators of Basal-Like Breast Cancer Reprogramming and Endocrine Therapy Vulnerability

Basal-like breast cancer is the most aggressive breast cancer subtype with the worst prognosis. Despite its high recurrence rate, chemotherapy is the only treatment for basal-like breast cancer, which lacks expression of hormone receptors. In contrast, lum

cancerres.aacrjournals.org

boolean network모델을 활용하여 basal-like 유방암을 luminal-A로 phenotype-switch시킬 때 필요한 therapeutic target을 찾은 논문임.

 

논문의 방법론을 이해하기 위해 필요한 논문

https://www.frontiersin.org/articles/10.3389/fphys.2018.00454/full

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