논문/논문리뷰 썸네일형 리스트형 Unified rational protein engineering with sequence-based deep representation learning Rational protein engineering requires a holistic understanding of protein function. Here, we apply deep learning to unlabeled amino-acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically rich and structurally, evolutionarily and biophysically grounded. We show that the simplest models built on top of this unified rep-resentation (Un.. 더보기 Gene essentiality for tumour growth influences neoantigen-directed immunoediting 일반적으로 항상 발현되는 유전자에서 발생한 neo-antigen은 clonal contraction (클론 축소) 경향이 일어나서 사라지는 경향으로 가지만 생존에 필수적이지 않고 발현이 되던 안되던 상관없는 유전자의 neo-antigen은 clonal expansion하는 경향이 있음. https://pubmed.ncbi.nlm.nih.gov/35060683/ 더보기 Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(21)00005-7 더보기 Resilience function uncovers the critical transitions in cancer initiation Considerable evidence suggests that during the progression of cancer initiation, the state transition from wellness to disease is not necessarily smooth but manifests switch-ike nonlinear behaviors, preventing the cancer prediction and early interventional therapy for patients. Understanding the mechanism of such wellness-to-disease transitions is a fundamental and challenging task. Despite the .. 더보기 Network Analysis Identifies Regulators of Basal-Like Breast Cancer Reprogramming and Endocrine Therapy Vulnerability https://cancerres.aacrjournals.org/content/early/2021/11/26/0008-5472.CAN-21-0621.long Network Analysis Identifies Regulators of Basal-Like Breast Cancer Reprogramming and Endocrine Therapy Vulnerability Basal-like breast cancer is the most aggressive breast cancer subtype with the worst prognosis. Despite its high recurrence rate, chemotherapy is the only treatment for basal-like breast cancer,.. 더보기 identification of COVID19-induced pathways reveals drug repurposing trategies https://www.science.org/doi/10.1126/sciadv.abh3032?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies Data-driven computational analysis and simulation identified drug repurposing opportunities for COVID-19. www.science.org 저자직강 동영상 https://www.youtube.com/watch?v=dqyzbC5ZSZA 더보기 Anticancer peptides prediction with deep representation learning features Briefings in Bioinformatics, 22(5), 2021, 1–14 https://doi.org/10.1093/bib/bbab008 더보기 논읽남 1. Proteogenomic integration reveals therapeutic targets in breast cancer xenografts 보호되어 있는 글입니다. 더보기 이전 1 다음